Tig Notaro received a giant career boost in 2012 after a series of personal setbacks and tragedies that included the death of her mother, the onset of a rare intestinal disease, and a diagnosis of breast cancer. She went on stage, at the Largo nightclub in Los Angeles, and performed a brutally honest, bravely uncomfortable comedy standup set that began with her telling the crowd, “I have cancer.” Louis C.K., who watched the set, released audio of it on his website, which became a No.